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	Provedor de dados BJMBR (1) BJPS (1) Autor Gu,J-J. (1) Heli,Hossein (1) Karimi,Maryam (1) Karimian,Khashayar (1) Liu,J-C. (1) Zhang,Y-S. (1) Mais... Palavra-chave Breast cancer cell (2) Anticancer drug (1) Bioavailability (1) Glivec (1) Heterometallic (1) Nanoemulsion (1) Single crystal (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy BJPS Karimi,Maryam; Karimian,Khashayar; Heli,Hossein. A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively. Tipo: Info:eu-repo/semantics/article Palavras-chave: Glivec; Nanoemulsion; Anticancer drug; Bioavailability; Breast cancer cell. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100640 Synthesis, crystal structure, and anti-breast cancer activity of a novel metal-porphyrinic complex [YK(TCPP)(OH)2·(solvents)x] BJMBR Liu,J-C.; Gu,J-J.; Zhang,Y-S.. A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of the porphyrins, which is seldom seen in MPFs. In addition, in vitro anticancer activity of complex 1 on three human breast cancer cells (BT474, SKBr-3 and ZR-75-30) was further determined. Tipo: Info:eu-repo/semantics/article Palavras-chave: Heterometallic; Single crystal; Breast cancer cell. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100611 Registros recuperados: 2 Primeira ... 1 ... Última

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